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生化试剂

CD9 Monoclonal Antibody (Ts9)

产品介绍【返回】

 
规格 库存 统一销售价
200ul 6 2385.00 

产品规格
种属反应
Human
已发表种属
Human, Mouse
宿主/亚型
Mouse / IgG1
分类
Monoclonal
类型
Antibody
克隆号
Ts63
抗原
Jurkat and HeLa (human cell lines)
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
purified
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
4° C
RRID
AB_2532983

产品详细信息

Tested in western blotting under non-reducing conditions.

靶标信息

CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. CD63 is also present in the plasma membrane, usually following cell activation. Hence, CD63 has become a widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas. CD63 is expressed on activated platelets, and is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. CD63 is also present in monocytes and macrophages and is weakly expressed on granulocytes, B, and T cells. CD63 is identical to the melanoma-associated antigen which is ME491 and to the platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.

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